Burnout is a multifaceted challenge plaguing the health care industry and therefore requires a multifaceted approach. This phenomenon has been researched for several decades and presents as an ongoing challenge in our modern work world. Beyond the buzz, burnout carries significant consequences for individuals, teams, and organizations. This introductory course provides health care professionals across all settings with essential information about evidence-based person- and work-level interventions to prevent, manage, and treat the root causes and symptoms of burnout. Health care professionals must proactively address burnout from various angles, including the implementation of practices geared toward enhancing personal psychological resources. Such interventions will foster a greater sense of well-being and work-life satisfaction and reduce the symptoms associated with burnout that carry destructive consequences for patients, teams, and organizations.