Clinical vignettes, or cases, represent the oldest and most familiar form of medical communication. A vignette presents a hypothetical situation to which learners respond, thereby revealing their perceptions, values, social norms, or impressions of events. This form of learning helps students recognize and interpret important data coming from the patient's problem, enabling students to arrive at a correct diagnosis and best treatment course. This course uses four different cases to discuss the most pertinent examination and treatment methods for each involved condition. This course is part of a comprehensive clinical series covering examination and intervention for the cervical, thoracic, and lumbar spine, as well as the upper (shoulder, elbow, wrist, and hand) and lower (hip, pelvis, knee, foot, and ankle) quarters.