So many people suffer from painful muscle trigger points as the result of stress, tension, and injury. The pain interferes with everyday activities and results in mobility impairments and participation limitations. Understand the nature of trigger points, (TPs) and how abnormal neurophysiological reflexes contribute to painful muscle tension and mobility impairments. Positional release (PRT) interventions modify abnormal reflexes to relax and release painful muscle tension, improving flexibility, strength, and function. Identify specific positions to manage TPs throughout the body, and objectively improve function and mobility. Discuss the research on the effectiveness of positional release techniques for pain reduction, strength and flexibility improvement, and performance enhancement.