Babies and children are often some of the most vulnerable populations to infection. Acute necrotizing encephalopathy is a rare diagnosis with poor prognostic factors, typically caused by a viral illness prior to onset. Many of those who survive have continued neurologic sequelae and it is essential that clinicians know of possible interventions that may assist in recovery and maintain or improve function. This presentation will describe the clinical features of acute necrotizing encephalopathy and any predisposing factors. Additionally, physical therapy interventions for a young child with acute necrotizing encephalopathy with neurologic clinical features will also be presented.